Comics/brain, brain, meme brain/Сomics meme: "Ligand binds GPCR
causing conformational
change shifting loop 5-6 Binds trimeric G
protein and acts
as a GEF, Gs Alpha
releases GDP
picks up GTP Gbu released from
Gs Alpha GTP
Stimulates Adenylyl
Cyclase Amplification of 2nd
messenger cAMP 2 cAMP binds r
subunits of PKA Both c subunits of
PKA are released
and active PKA phosphorylates
Various enzymes
depending on cell
type"
Сomics meme: "Ligand binds GPCR
causing conformational
change shifting loop 5-6 Binds trimeric G
protein and acts
as a GEF, Gs Alpha
releases GDP
picks up GTP Gbu released from
Gs Alpha GTP
Stimulates Adenylyl
Cyclase Amplification of 2nd
messenger cAMP 2 cAMP binds r
subunits of PKA Both c subunits of
PKA are released
and active PKA phosphorylates
Various enzymes
depending on cell
type"